alexa Abstract | Unveiling Hypothetical Proteins of Ganoderma: An Endeavour in Functional Annotation Using In silico Tools

Journal of In Silico & In Vitro Pharmacology
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Research Article Open Access

Abstract

Proteins mediate multitude of housekeeping functions vital for cell integrity and survival and even infinitesimally small aberration in protein functioning can cause numerous abnormalities. Numerous therapeutic effects observed in Ganoderma species directed the researchers to characterize protein sequences which may possess the potential to impart new edges to immune function and designing effective drugs. Although, numerous fungal proteins have been annotated, functions have not yet been assigned to 33 mitochondrial proteins of this fungus belonging to the genus of polypore mushrooms. Annotating functions of Ganoderma carried out for the first time, divulged parameters decisive in characterization including localizations of the protein, motif, domain, cluster, phylogenetic relationship, and protein interaction with other molecules. The information obtained using various bioinformatics tools results in functional annotation of proteins which plays role as integrase, prefoldin, endonuclease, dehydrogenase, polymerase, GIY-YIG endonuclease, LAGLIDADG endonuclease and reverse transcriptase.



Author(s): Sanjeev Kumar Balraj Singh Gill and Navgeet

Keywords

Ganoderma lucidum (GL), Hypothetical proteins (HPs), Bioinformatics tools, Pharmaceutics, Novel Drug delivery systems, Pharmacy Practice, Pharmacogenomics, Pharmacophore.

 
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