alexa Abstract | Validated spectrophotometric determination of Fenofibrate in formulation

Der Pharmacia Sinica
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Research Article Open Access

Abstract

The aim of present work is to develop and validate spectrophotometric methods for the determination of fenofibrate, an anti-hyperlipidemic, fibric acid derivative in pharmaceutical formulation. Methanol was used as a solvent throughout the study. Quantitative determination of fenofibrate in pharmaceutical formulation was carried out by UV-spectrophotometric method using the absorbtivity values at 287.5 nm and by comparison with standard (method 1a and 1b) and the first order derivative absorbance values at 249.2 nm were utilized for estimation of drug (method 2). The method showed high specificity in the presence of formulation excipients and good linearity in the concentration range of 0-60 μg/mL. Percent recovery values at 287.5 nm were 100.3% while it was 100.18% at in 1st order derivative spectrophotometry at 249.2 nm (n=3). SD values showed that both spectrophotometric methods were reproducible. The intra and interday precision data demonstrated that method is precise.

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Author(s): Krishna R Gupta Sonali S Askarkar Prashant R Rathod and Sudhir G Wadodkar

Keywords

Fenofibrate, capsules, tablets, Derivative spectrophotometry

 
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