alexa Abstract | Validation Of A RP-LC Method For Simultaneous Determination Of Paracetamol, Methocarbamol And Diclofenac Potassium In Tablets

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication Open Access


A simple, fast, precise and accurate liquid chromatographic method was developed for the simultaneous estimation of paracetamol, methocarbamol and diclofenac potassium in tablets. Drugs were chromatographed on a reverse phase Hypersil C18 column using a mobile phase, 25 mM phosphate buffer (pH adjusted to 7.0±0.1) and acetonitrile in the ratio of 65:35 v/v. The flow rate was 1.2 ml/min and the effluent was detected at 225 nm. Chlormezanone was used as an internal standard. The retention time of paracetamol, methocarbamol and diclofenac potassium were 2.74, 3.82 and 6.05 min, respectively. The method was linear (correlation co-efficient was more than 0.999), precise (percentage residual standard deviation for 0.15 for paracetamol, 0.17 for methocarbamol and 0.16 for diclofenac potassium), accurate (overall mean average recovery yields: 99.9% for paracetamol, 100% for methocarbamol and 101% for diclofenac potassium) and selective. Due to its simplicity and accuracy, the method was suitable for routine quality control analysis of these drugs in combined dosage form.

To read the full article Peer-reviewed Article PDF image

Author(s): G Subramanian M Vasudevan S Ravisankar B Suresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version