alexa Abstract | Variability Of Serum Phenytoin Concentrations In Indian Epileptic Patient Population

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication Open Access


Due to varied pharmacokinetic behavior and inter individual variation of phenytoin, serum level monitoring is necessary to optimize the drug therapy. The present study was designed to study the relationship between serum levels of phenytoin and different patient related factors like the dose administered, effects of age, sex, control of seizures and the influence of co-medication on the phenytoin concentration. Blood samples were collected from the selected patient group (126 patients) and analyzed using a sensitive HPLC method. Of the 111 patients receiving phenytoin as mono therapy, complete seizure control could be achieved in 80 patients. Seventy four percent of these patients had seizures completely controlled with serum phenytoin level below therapeutic range. The following are the conclusions: In the epileptic patients on monotherapy, the seizure control with phenytoin was observed in the concentration range of 3.9 to 29 μg/ml with a mean (±SD) of 11.56±13 μg/ml. Patients showing therapeutic benefit ranged with serum drug level from sub therapeutic level to toxic level indicating the reference therapeutic range (10 to 20 μg/ml) has to redefined for Indian epileptic patient population.

To read the full article Peer-reviewed Article PDF image

Author(s): P Kishore K Manohar T Umesh J Vidya Sagar D R Krishna

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version