alexa Abstract | Virtual screening of enzyme inhibitory activity of active components of Spirulina fusiformis against selected enzymes involved in glycemic control

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


Diabetes mellitus (DM) has affected 7% of the world’s adult population. Spirulina fusiformis is a rich nutritional supplement which is non-toxic and has antidiabetic, antioxidant and hypolipidaemic activity. Our study was aimed to investigate the in silico inhibitory effect of the chosen active compounds of Spirulina(3Z-phycocyanobilin, β- carotene and Vitamin B12) against human xanthine oxidoreductase, human glycogen synthase kinase 3-β, α- glucosidase, human aldose reductase and α-amylase. The docking experiments were carried out using Patch Dock server. PyMol molecular viewer was used for the analysis of patterns of interaction of the ligands against the chosen receptors. Vitamin B12 revealed significant interactions showing six hydrogen bonds each with human xanthine oxidoreductase and human glycogen synthase kinase 3-β.The potential of vitamin B12 in this regard needs to be studied further by appropriate in vivo models.

To read the full article Peer-reviewed Article PDF image

Author(s): Kadar Basha S Giridharan R Jerine Peter S Udhaya Lavinya B and Evan Prince Sabina


Spirulina, Active components, Diabetes, Insilico, Spirulina fusiform

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version