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Short Communication Open Access
A new spectrophotometric method is developed for the estimation of lomefloxacin hydrochloride (LFLX) in pharmaceutical dosage forms. The method is based on the reaction of LFLX with 1% W/V ferric nitrate solution in 1 % v/v nitric acid to form orange yellow coloured chromogen which exhibits absorption maximum at 445 nm. The Formation of colored chromogen is due to the interaction of quinolone derivatives with polyvalent metal ion Fe++, to form water soluble complex1. The chromogen formed is stable. Beer's law is obeyed in the concentration range of 2-10 mcg/ml.
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Author(s): A Rajasekaran B Jaykar S Dhanalakshmi M Deepalakshmi V Irine Beulah