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Original Articles Open Access
The present study was carried out to evaluate the wound healing potential of crude aqueous extract of Barringtonia acutangula fruit (AEBA) ointment in experimental animals. All experiments were conducted following standard procedures. The crude extract ointment was administered topically in graded doses of 5% w/w, 10% w/w and 20% w/w for evaluating the wound healing potential in excision wound and incision wound model for fourteen days. Povidone iodine ointment 5% w/w was used as standard. Dose dependent activities resulted in both the wound models when compared to the standard (povidone iodine) and the control. Topical application of AEBA 20% w/w in excision wound model decreased significantly the wound area by 14th day, i.e. 67±2.12 compared with control 238.5±1.17. Similarly in incision wound model there is significant (232.66±2.20) increase in breaking strength of wounds when compared with control (107.5±15.09). Histological examination further supported wound healing activity of AEBA (20% w/w). There was mild healing was observed in 5%w/w & 10%w/w of AEBA and no healing was observed in negative control group. So, AEBA accelerated wound healing activity in rat and thus supports its traditional use.
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Author(s): Arnabaditya Mohanty and Pratap Kumar Sahu
Barringtonia acutangula, Excision, Incision wound, Histopathology, Barringtonia acutangula