alexa Abstract | Zonisamide: Antiproliferative and Antioxidant Effects on C6 Glioma Cancer Cell Model

Archives in Cancer Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Seizures are often seen in patients with brain tumors and antiepileptic drugs such as acetazolamide, valproic acid. Some of these antiepileptic drugs also have anti-cancer effects that have been shown in many studies. For instance, valproic acid has been shown to be related to apoptosis pathway and induced the suppression of C6 glioma cell migration. Zonisamide is also commonly used as an antiepileptic drug because of its scavenging effects on hydroxyl and nitric oxide radicals. Due to valproic acid’s anticancer activity, zonisamide was investigated for its antiproliferative and antioxidant effects on C6 glioma cells. The percentage of cell viability, measurement of DNA synthesis, superoxide dismutase activity and the measurement of glutathione were studied in the presence of zonisamide. IC50 value of zonisamide is 80 M at 48 hour. According to DNA synthesis (BrdU incorporation) analysis, IC50 value and lower concentration (50 M) of zonisamide reduced the rate of C6 glioma DNA synthesis significantly as compared to control cells. Zonisamide was also decreased SOD and GSH levels on glioma C6 cells depending on concentrations and incubation of time. Using of zonisamide with anti-cancer agents fighting against glioma cells might be useful because of its antiproliferative effects.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Zeynep Bor Zerrin Incesu Nurcan Bektas and Rana Aslan


Zonisamide, C6 glioma cells, Anticancer, Antioxidant, Molecular Cancer Therapeutics, Cancer therapeutics, Brain tumor

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us