alexa Abstract | Adipose-Derived Stem Cells (ASC) Communicate with Residual Breast Cancer Cells
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

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Review Article Open Access

Abstract

Purpose: Based on aesthetics and long-term stability, call-assisted autologous lipotransfer is a promising method for post-oncological breast reconstruction. Thereby, autologous fat grafts enriched with autologous adiposederived stem cells are transferred to the breast. However, as adipose-derived stem cells (ASC) have the ability to secrete exosomes and growth factors, they could communicate with residual breast cancer cells.

Methods: We performed a systematic review of the published literature to evaluate whether adipose-derived stem cells- based treatments for breast cancer are associated with tumor growth of rest breast cancer cells and therefore that it could exist an oncological risk. An electronic database search was performed.

Results: As described, all current studies can prove that the gene expression is influenced by the direct cell contact between adipose-derived stem cells and breast cancer cells.

Conclusion: These observations suggest that information is substituted via exosomes which can migrate intercellularly and transfer genetic material between both cell types.

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Author(s): Reinkens T, Vogt PM and Bucan V

Keywords

Adipose-derived stem cells, Exosomes, Autologous lipotransfer, Breast cancer, Adipose-derived stem cells, Exosomes, Bioactive Compound, Cellular Medicine, Epigenomics, Gene Therapy, Genetic Engineering in Medicine, Genomic Medicine, Human Molecular Genetics, Medicinal Biotechnology, Metabolomics, Molecular Basis of Cancer, Molecular Basis of Obesity, Molecular Diagnosis, Molecular Genetic Test, Molecular Medicine, Nuclear Medicine, Pathology and Molecular Medicine, Personalized Medicine

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