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Research Article Open Access
Background: Clinical epidemiology studies of breast cancer in India have reported younger age at detection, presentation at a later stage with a greater proportion of Triple Negative Breast Cancer (TNBC). The aim of this study was to examine the standard clinic-pathological variables in the hormone-receptor based sub-types for patterns indicative of intrinsic differences from that reported in Western, Caucasian women.
Methods: Clinico-pathological variables from 645 patients who were diagnosed with breast cancer during 2012 at the regional cancer were retrospectively analyzed for clinical and immunohistochemistry details.
Results: The median age at first diagnosis is 48 years which is decade earlier than that reported in Western case-series, 65% were lymph-node positive, and 33% of all cases were Triple negative Breast Cancers. Sub-type specific examination of tumor size and lymph-node (LN) status showed the HER2 positive tumors to have the highest proportion of tumors that were pT4 and 75% were LN positive. Conversely, despite 92% of TNBCs being grade 3, 40% of them were LN negative.
Conclusion: We confirm the three cardinal clinical epidemiological features reported by other Indian centres. The clinical behavior of the HER2 positive and TNBC sub-types are no different from that reported in Western caseseries suggesting that these aspects are innate and conserved.
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Author(s): Geetashree Mukherjee, KC Lakshmaiah, M Vijayakumar, Jyothi S Prabhu, Deepthi Telikicherla, TS Sridhar and Rekha V Kumar
South-India, Breast cancer sub-types, TNBC, Clinicopathological presentation, Cellular Oncology, brain tumour, SNP,Antibody Therapy