alexa Antidiabetic Potential and its Relationship with Polyphenol and Degree of Polymerization in Acalypha indica Linn Leaves | Abstract

Journal of Traditional Medicine & Clinical Naturopathy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Acalypha indica commonly known as Kuppi belongs to family Euphorbiaceae. Traditionally the plant used as a laxative, anthelmintic, cathartic and the juice is used as a speedy emetic for children and expectorant. It is used by tribal areas of Maharashtra State as rheumatic arthritis and as antihyperglycemic. However, no scientific data is available to validate the ethnobotanical claim. Keeping the above information in view, the present study has been designed to evaluate its antidiabetic activity. In the present study, hydroalcoholic extract of leaves and its fractions were studied for its anti diabetic potential in alloxan induced diabetic rats. The poly phenolic, flavonoid and flavanone contents of hydroalcoholic extract and its fractions were also determined and correlated with its anti diabetic activity.

The experimental data indicated that the hydroalcoholic extract and its chloroform soluble fraction has significantly lowered the elevated blood glucose levels by 36.82% and 61.52% respectively at dose level of 400 mg/kg per oral after 7 days as compared to diabetic control. The poly phenolic and flavonoid content of hydro alcoholic extract and its chloroform soluble fraction were found to be 7.9 ± 0.20 mg and 1.14 ± 0.21mg (gallic acid equivalent/ g extract) and flavonoid content 2.02 ± 0 .50 mg and 0.56 ± 0.003mg (rutin equivalent/g extract) respectively.

The increased anti diabetic potential of chloroform fraction over hydro alcoholic extract is due to its partial purification achieved by fractionation which resulted in increase in degree of polymerization and segregation of secondary metabolites.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Prakash R Itankar, Akash P Jaiswal, Prashant R Verma, Sumit K Arora and Arun T Patil

Keywords

Holistic Nutrition, Naturopathy, Naturopathic Medicine, Prediabetes

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords