alexa Abstract | Anti-inflammatory Effects of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor on Acute Coronary Arteritis in A Rabbit Model of Kawasaki Disease
ISSN: 2329-6925

Journal of Vascular Medicine & Surgery
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Background: Recent observations suggest that some of the clinical benefits associated with statin therapy are pleiotropic, i.e., they are independent of their cholesterol-inhibiting action. In this study, we attempted to evaluate the anti-inflammatory effects of statins on coronary arteritis in a rabbit model of Kawasaki disease (KD).
Methods and Results: Allergic vasculitis rabbit models were used in this study and divided into 3 groups as follows: no treatment (A), fluvastatin treatment (B), and pravastatin treatment (C). In group A, histological examinations demonstrated severe panvasculitis with endothelial destruction, marked mononuclear cell infiltration of all layers, and edematous thickening of the medial layer. These inflammatory findings were most prominent on day 3 and were similar to the histopathological features in KD. However, in both groups B and C, the inflammatory findings were significantly suppressed even on day 3 in comparison with those in group A.
Conclusions: Our study showed that statins had significant anti-inflammatory effects in a rabbit model of acute coronary arteritis typical of KD. It is suggested that statins may be effective for preventing the development of coronary aneurysmal changes.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Kenji Hamaoka*, Seiichiro Ozawa and Kazuyuki Ikeda


3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, Allergic vasculitis, Endothelial cell, Animal model, Kawasaki disease, Embolism, Pulmonary artery trunk, Aortic dissection, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, Allergic vasculitis, Endothelial cell, Animal model, Kawasaki disease

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version