alexa Abstract | Antioxidative and Anti-Inflammatory Potentials of Ambroxol in Ameliorating Vincristine Induced Peripheral Neuropathic Pain in Rats
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


The present study was designed to investigate the ameliorative potential of Ambroxol, a voltage gated sodium channel 1.8 (VGSC 1.8) inhibitor in Vincristine induced neuropathic pain in rats. Administration with Vincristine (75 μg/mg, intraperitoneal) for 10 consecutive days induces neuropathic pain. Hyperalgesia and allodynic symptoms were assessed with various behavioral models i.e., paw thermal-heat hyperalgesia, tail cold hyperalgesia and paw cold allodynia via hot-plate test, cold-water tail immersion test and acetone drop test at different time intervals of 0,1,7,14, and 21 days. Oxidative stress markers i.e., thio-barbituric acid reactive substances, superoxide anion content and inflammatory mediators like tumor necrosis factor-alpha and myeloperoxidase were biochemically assessed from sciatic nerve tissue and surrounding muscular tissue homogenates respectively. Pharmacological cotreatments with Ambroxol (1000 mg/kg, per oral), Carbamazepine (100 mg/kg, per oral) and combination of Ambroxol with Pregabalin (10 mg/kg, per oral) for 14 days, significantly ameliorate the Vincristine induced neuropathic pain in terms of attenuating paw thermal hyperalgesia, tail-cold hyperalgesia and paw cold allodynia along with decrease in oxidative stress markers and inflammatory mediators. Therefore, on the basis of data in hand from present study, it has been concluded that Ambroxol have neuroprotective potential in ameliorating Vincristine induced neuropathic pain in rats.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Bhardwaj HC, Muthuraman A, Hari KSL and Navis S


Nervous System, Viral Infection, Fungal Infection, Neuroinfectious Agents, Non-Polio Enterovirus Infections, Opisthorchis Infection,Sinus Infections,Central nervous system vasculitis,Central nervous system vasculitis

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version