alexa Abstract | Biochemical Structure and Functions of the Lumbar Disc after an Autologous Chondrocyte Transplantation (ACT) Evaluated by Studies of Two Operated Cases of Repeated Disc Herniation
ISSN: 2165-7939

Journal of Spine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Transplantation of autologous chondrocytes obtained from cellular culture constitutes one of the methods of the biological treatment of the degenerative disc disease (DDD). The study covered a group of 50 patients operated on for single-level lumbar discopathy in whom material for autologous chondrocyte culture was sampled from a removed fragment of an intervertebral disc. The chondrocytes obtained from the culture were next implanted into the pre-operated space with the use of the percutaneous method, the implantation being followed by a radiological and clinical evaluation. In two cases a repeated prolapse of a nucleus pulposus fragment was reported after an earlier transplantation. The patients were operated on again. The material obtained from the recurred nucleus pulposus hernia allowed for a biological evaluation of the effect of the transplantation on the structure of the intervertebral disc with a light and confocal microscope. The examination showed good integration of the transplanted cells with the cellular matrix and their correct production activity in the form of the generation of typical matrix components – type I, II, III, IX collagen, proteoglycans and aggrecan as well as type IV collagen, atypical for the matrix, the presence of which is a subject of further research works.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Abaaslam F, Marszałek P, Głowacki M, Włuka A, Sierzputowski T and Czernicki Z

Keywords

Lumbar disc, Chondrocytes, Disc herniation, Spine, Spine,Spinal Canal,Spinal arteriovenous malformations

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords