alexa Abstract | Brain Fires in Autism Spectrum Disorders
ISSN: 2090-7214

Clinics in Mother and Child Health
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article Open Access

Abstract

Autism spectrum disorders (ASD) is characterized by social and communicative deficits, severe anxiety, and stereotypic movements. Despite affecting as many as 1 in 45 US children in the USA, the pathogenesis of ASD is still unknown. Recent epidemiological studies indicated a strong statistical correlation between risk for maternal / infant atopic diseases and ASD suggesting the possible involvement and activation of mast cells (MC). These unique immune cells are located close to blood vessels in all tissues, including the thalamus and hypothalamus in the brain, which regulate emotions known to be dysfunctional in ASD. Moreover, MCs are stimulated by two brain peptides, corticotropin-releasing hormone (CRH) and neurotensin (NT), which we showed to be high in the blood of children with ASD. Stimulated MCs then secrete inflammatory molecules that activate brain microglia, which proliferate and “choke off” nerve communication. These inflammatory molecules are increased in the brain and serum of patients with ASD and also lead to disruption of the protective blood brain barrier (BBB), which is regulated by MCs, permitting the entry of circulating white blood cells and toxins contributing to brain. We further reported that the elevated blood levels of two inflammatory molecules, IL-6 and TNF, identify a subgroup of children with ASD, who benefit most from a promising treatment with the natural flavonoid luteolin that combats brain inflammation. Extinguishing inflammation (“Brain fires”) may be the best hope for curing ASD.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Theoharides TC, Stewart JM, Athanassiou M

Keywords

Care to be Taken for New Borns

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords