alexa Abstract | Cellular Senescence by the Epigenetic Regulators Inhibitor of Growth
ISSN: 2329-8847

Journal of Aging Science
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article Open Access

Abstract

The epigenetic regulatory tumor suppressor, INhibitor of Growth 1 (ING1), obtained more focus since it has been suggested as one of the aging-related candidate genes among healthy elderly individuals. ING1 belongs to the ING family proteins characterized by a plant homeodomain (PHD), which is important for recognizing and binding to histone marks, thus allowing ING to regulate genes expression through histone modification and chromatin changes. Interestingly, the PHD of ING proteins is highly conserved among species between mammals, insects and plants. The ING factors regulate the program of cellular senescence and DNA repair, which are suggested to have a protective role in inhibiting cancer cells proliferation. Here, we provide an insight into the functional role of ING factors in development and tumor cells.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Thanakorn Pungsrinont and Aria Baniahmad

Keywords

ING, Senescence, Cancer, Epigenetics, Aging, PHD, Evolution

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords