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Review Article Open Access
The epigenetic regulatory tumor suppressor, INhibitor of Growth 1 (ING1), obtained more focus since it has been suggested as one of the aging-related candidate genes among healthy elderly individuals. ING1 belongs to the ING family proteins characterized by a plant homeodomain (PHD), which is important for recognizing and binding to histone marks, thus allowing ING to regulate genes expression through histone modification and chromatin changes. Interestingly, the PHD of ING proteins is highly conserved among species between mammals, insects and plants. The ING factors regulate the program of cellular senescence and DNA repair, which are suggested to have a protective role in inhibiting cancer cells proliferation. Here, we provide an insight into the functional role of ING factors in development and tumor cells.
ING, Senescence, Cancer, Epigenetics, Aging, PHD, Evolution