alexa Abstract | Comparative Study on the Effect of Various Superdisintegrants in the Formulation of Ibuprofen Fast Dissolving Tablets


Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

In the present study, an attempt has been made to formulate fast dissolving tablets of Ibuprofen. Tablets were prepared using a direct compression method employing superdisintegrants such as Kyron T-314, sodium starch glycolate (Explotab), croscarmellose sodium (Ac‐Di‐Sol), and crospovidone. The prepared tablets were evaluated for their physiochemical properties like wetting time, water absorption ratio, dispersion time, disintegration time and in vitro drug release studies. It was observed that the results obtained from formulations containing the Kyron T-314 and CP as superdisintegrants showed a better profile in comparison to CCS and SSG. The hardness of the tablets was in the range of 3.0 ‐ 4.0 Kg/cm². The percent weight variation of the tablets was below the range. Weight variation test results showed that the tablets were deviating from the average weight within the permissible limits of ±7. 5 %. Drug content uniformity study results showed the uniform dispersion of the drug throughout the formulation, i.e. 97.24% to 99.98%. Tablets of ibuprofen prepared using cross povidone (CP) exhibited the least friability and disintegration time 54 seconds along with the rapid release (99.81% drug within 15 min) CP was found to be better suited for the formulation of the fast dissolving tablet of ibuprofen compared to other superdisintegrants used in the study. Stability studies indicated that there are no significant changes in hardness, percentage friability, drug content and in-vitro disintegration time and cumulative percentage drug release (%CDR).

To read the full article Peer-reviewed Article PDF image

Author(s): Swatantra Bahadur Singh, Shweta Singh, Anil Kumar Sharma

Recommended Journals

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords