Journal of Infectious Diseases & Therapy
Open Access

Case Report

Complete Remission of Primary Cutaneous Cryptococcosis in an Immunosuppressed Patient after Fluconazole Treatment

Landucci G¹, Farinelli P², Zavattaro E^3*, Giorgione R², Gironi LC², Veronese F¹, Astolfi S², Tiberio R², Boldorini RL¹, Colombo E³ and Savoia P¹

¹Department of Health Sciences, University of Eastern Piedmont, Novara, Italy

²Maggiore della Carita University-Hospital, Novara, Italy

³Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy

*Corresponding Author:

Elisa Zavattaro
Department of Translational Medicine
University of Eastern Piedmont
Via Solaroli 17, 28100, Novara, Italy
Tel: 39 0321 3733269
Fax: 39 0321 3733586
E-mail: elisa.zavattaro@med.uniupo.it

Received date: June 25, 2017; Accepted date: July 20, 2017; Published date: July 26, 2017

Citation: Landucci G, Farinelli P, Zavattaro E, Giorgione R, Gironi LC, et al. (2017) Complete Remission of Primary Cutaneous Cryptococcosis in an Immunosuppressed Patient after Fluconazole Treatment. J Infect Dis Ther 5:326. doi: 10.4172/2332-0877.1000326

Copyright: © 2017 Zavattaro E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cryptococcus neoformans is opportunistic encapsulated yeast that represents the most frequent cryptococcal species found in humans. It can cause three types of infections: pulmonary cryptococcosis, cryptococcal meningitis and cutaneous cryptococcosis. Cutaneous cryptococcosis may represent the dissemination of a systemic infection (especially from nervous or pulmonary primary site of infection) or may be the only localization, due to a direct inoculation into the skin, because of a traumatic injury. Primary cutaneous cryptococcosis (PCC) is rare and mainly affects elderly patients, from rural areas, with history of cutaneous injuries and activities predisposing wounds or exposure to bird droppings. Immunosuppression may be a predisponing factor. The most utilized treatment is fluconazole, but often, especially for ulcers or deep wounds; surgery is required for complete tissues repair. Herein, we present a case of PCC in an immunosuppressed patient, with destroying ulcers involving deep tissues, completely resolved after fluconazole treatment, without surgical intervention.

Keywords