alexa Cordycepin from Hot Water Extract of Cordyceps militaris Induce Apoptosis in Human Non-Small Lung Carcinoma upon Activation of A3 Adenosine Receptors | Abstract

Journal of Traditional Medicine & Clinical Naturopathy
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Cordyceps militaris hot water extract (CMHW) containing cordycepin (cordycepin-CMHW) was used to study the anti-cancer effects in human A549 non-small cell lung carcinoma cells. Our results showed cordycepin-CMHW can inhibit cell proliferations in A549 cells by activating A3 adenosine receptor (A3AR) via the inactivation of Akt pathways. Cordycepin-CMHW can also induce apoptosis in the A549 cells by enhancing DNA fragmentation and chromatin condensation. We further observed that cordycepin-CMHW up-regulated caspase-9 and increased cleavage of caspase-3 and poly ADP ribose polymerase (PARP) in A549 cells. The results suggested cordycepin-CMHW is a highly selective treatment to de-regulation of the cell proliferation and apoptosis in non-small cell lung carcinoma via signaling pathways generated by A3AR activation

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Author(s): Felix Shih-Hsiang Hsiao, Yu-Hsiang Yu, Pramod Shah, Witold Stanisław Proskura, Andrzej Dybus, Ching-Han Huang, Yi-Lin Chen and Yeong-Hsiang Cheng


Cordyceps militaris, Cordycepin, A3AR, Apoptosis, Acupuncture Therapy,Traditional Chinese Medicine

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