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Hindi Research Article
Correlation of LDL Cholesterol with Maternal and Cord Blood Heme Oxygenase 1 in Preeclampsia
| Kharb S*, Tiwari R and Nanda S | |
| Department of Biochemistry, Sharma University of Health Sciences, Rohtak, Haryana, India | |
| Corresponding Author : | Kharb S Department of Biochemistry Sharma University of Health Sciences Rohtak, Haryana, India Tel: 919812016036 E-mail: simmikh@gmail.com |
| Received: January 29, 2016 Accepted: February 19, 2016 Published: February 26, 2016 | |
| Citation: Kharb S, Tiwari R, Nanda S (2016) Correlation of LDL Cholesterol with Maternal and Cord Blood Heme Oxygenase 1 in Preeclampsia. J Preg Child Health 3:225. doi:10.4172/2376-127X.1000225 | |
| Copyright: © 2016 Kharb S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Objective Emerging evidence supports an important role for the heme oxygenase system (HO-1) in the maintenance of a healthy pregnancy, especially during pathological challenge. HO-1 is widely accepted to be a highly sensitive and reliable marker of oxidative stress. Hence the present study was planned to analyse heme oxygenase-1 and lipid profile in maternal and cord blood venous samples of normal pregnant and preeclamptic women. Methods Fifty pregnant women were selected and grouped as group 1 (control) comprising of twenty five normotensive women immediately after delivery; group 2 (study group) comprising of age-and sex-matched twenty five preeclamptic women. Study samples were drawn (maternal venous blood and umbilical cord blood) and heme oxygenase-1 was analyzed by competitive enzyme linked immunosorbent assay and lipid profile was analyzed enzymatically. Results Cord blood hemeoxygenase-1 levels in preeclamptic women were significantly higher than those of normotensive women (p<0.001). There was significant rise in serum heme oxygenase 1 levels in preeclamptic women as compared to normotensive pregnant women (p<0.001). LDL levels were positively correlated with HO 1 in preeclamptic women (r=0.236, p>0.05) and negatively correlated in normotensive women (r=-0.111, p>0.05), indicating the induction of HO 1 by LDL. Conclusion The findings of high serum heme oxygenase-1 levels in maternal and cord blood in preeclampsia supports the role of oxidative stress and excessive inflammatory response in the pathogenesis of preeclampsia.
