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Research Article Open Access
Objective Emerging evidence supports an important role for the heme oxygenase system (HO-1) in the maintenance of a healthy pregnancy, especially during pathological challenge. HO-1 is widely accepted to be a highly sensitive and reliable marker of oxidative stress. Hence the present study was planned to analyse heme oxygenase-1 and lipid profile in maternal and cord blood venous samples of normal pregnant and preeclamptic women. Methods Fifty pregnant women were selected and grouped as group 1 (control) comprising of twenty five normotensive women immediately after delivery; group 2 (study group) comprising of age-and sex-matched twenty five preeclamptic women. Study samples were drawn (maternal venous blood and umbilical cord blood) and heme oxygenase-1 was analyzed by competitive enzyme linked immunosorbent assay and lipid profile was analyzed enzymatically. Results Cord blood hemeoxygenase-1 levels in preeclamptic women were significantly higher than those of normotensive women (p<0.001). There was significant rise in serum heme oxygenase 1 levels in preeclamptic women as compared to normotensive pregnant women (p<0.001). LDL levels were positively correlated with HO 1 in preeclamptic women (r=0.236, p>0.05) and negatively correlated in normotensive women (r=-0.111, p>0.05), indicating the induction of HO 1 by LDL. Conclusion The findings of high serum heme oxygenase-1 levels in maternal and cord blood in preeclampsia supports the role of oxidative stress and excessive inflammatory response in the pathogenesis of preeclampsia.
Heme oxygenase, Oxidative stress, Cord blood, Preeclamptic, Pregnant, Preclampsia in Pregnancy, Pregnancy Care, Pregnancy Constipation, Pregnancy Fitness, Pregnancy Nutrition, Smoking in Pregnancy, Stress in Pregnancy