alexa Abstract | Dermoscopic-pathologic Correlation of Bowen Disease: A Case Series and Review of the Literatures
ISSN: 2472-128X

Journal of Clinical & Medical Genomics
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Research Article Open Access

Abstract

Introduction: We report the dermoscopic and pathologic features of the four patients with Bowen disease, an insitu squamous cell carcinoma, to assess the correlation of the pathologic-dermoscopic features of the Bowen disease. Materials and Methods: Dermoscopic images of all cases including nine lesions of the four patients were obtained by means of microderm. The images were analyzed by two experienced observer for searching global and local dermoscopic features. Four of nine lesions were excised and submitted for histopathologic examination. Results: The most frequently occurring dermoscopic features were found to be: glumerolar vessels (88.8%), gray to brown pigmentation (77.7%), scaling (55.5%), homogenous pigmentation (55.5%) and pigmented steak (22.2%). The histopathological evaluation of all cases revealed the dysmaturation of the keratinocytes, keratinocytic atypia and irregular psoriasiform acanthosis. In dermoscopic-histopathologic correlation, all lesions showed glomerular vessels in dermoscopy except one of the lesions. Conclusion: Dermoscopy may be considered as a helpful diagnostic test for the bowen disease to rule out other differential diagnosis. The microscopic slide may not be completely representative of the dermoscopic features, therefore, serial sections could be ordered. Further study is needed to assess the specificity and sensitivity of the dermoscopic criteria in differentiating BD from other pigmented and nonpigmented skin tumors as well as from inflammatory skin disorders.

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Author(s): Hayadeh Ghaninejad, Sahra Emamzadehfard, Kambiz Kamyab-Hesari, Homayoun Moslehi and Alireza Ghannadan

Keywords

Dermoscopic, Bowen disease, Case series, Pigmented skin lesions, Genetic Diseases, Clinical Research in Genome

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