alexa Diagnosis of Atlantoaxial Instability Requires Clinical Suspicion to Drive the Radiological Investigation | Abstract
ISSN: 2165-7939

Journal of Spine
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Abstract

Atlantoaxial instability (AAI) occurs as a result of trauma, congenital conditions such as os odontoideum, neoplasm, infection and degenerative connective tissue disorders such as rheumatoid arthritis, genetic conditions such as HOX-D3 and Down syndrome, and heritable connective tissue disorders, emblematic of which are the Ehlers Danlos syndromes (EDS). Prototypical of disorders in which AAI is diagnosed, is rheumatoid arthritis (RA). Prior to the development of effective disease-modifying pharmacotherapies, 88% of RA patients exhibited radiographic evidence of C1-C2 involvement, in whom 49% were symptomatic and 20% myelopathic; ultimately, 10% may have suffered atlantoaxial dislocation and death.

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Author(s): Fraser C Henderson Sr. and Fraser C Henderson Jr.

Keywords

Atlantoaxial instability, Connective tissue, Rheumatoid arthritis, Spinal Canal,Spinal Diseases,Spinal arteriovenous malformations

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