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Research Article Open Access
Objective: As no studies were reported from Bangladesh, the present study was conducted on serum lipid profile, i.e. triglyceride TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoproteincholesterol (HDL-C) in Bangladeshi patients with cholelithiasis
Patients and methods: A total of 44 adult patients with cholelithiasis and 30 healthy subjects as normal controls (NC) were included in the study. The blood samples were taken from fasting patients at diagnosis before cholecystectomy (Serum-I0), gall bladder bile during cholecystectomy (Bile- I0) and blood sample again after 2-3 months at follow-up (Serum-II0) and from fasting NC subjects. TG, TC, LDL-C and HDL-C were quantitated in serum and bile by standard methods using research kits from reputed companies. The results were compared statistically by ANOVA and Student’s t-test using SPSS propramme
Results: TG level was elevated in Serum- I0 , Bile- I0 and Serum- II0 of patients, being highest in Bile- I0 compared to controls (NC) (p<0.001). TG level was reduced in serum -II0 after cholecystectomy compared to Serum- I0 and Bile- I0, although it remained significantly elevated compared to controls (NC) (p<0.001). TC level was elevated in Bile- I0 compared to Serum- I0 and Serum- II0 (p<0.001). Interestingly, TC was elevated in Serum- II0 after cholecystectomy, although no significant difference was observed between NC and patients Serum- I0 (p=0.835). LDL-C levels in NC, Serum- I0 and Serum- II0 were similar (p=0.126, p=0.121), although Serum-II0 levels was elevated compared to Serum- I0 (p<0.001) and it was much elevated in Bile- I0 (p<0.001). HDL-C levels were similar (p>0.05) among NC, Serum- I0 and Serum- II0, but it was higher in Bile- I0 significantly (p<0.001).
Conclusion: Alterations in lipid profile in cholelithiasis were significant but complex and cholecystectomy had profound impact suggesting a crucial role of gall bladder. The results were discussed accordingly.
Cholelithiasis, Cholecystectomy, Lipid profile, Triglyceride, Cholesterol, LDL-C, HDL-C, Metabolic syndrome, Atherosclerosis, Hepatokines, Diabetes