alexa Enhancing the Activity of Peroxisome Proliferator- Activated Receptors (PPAR) Activity through Natural Ligand Binding in Diabetes: Substantial Computational Approach | Abstract
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Background: Traditional medicines have been potential in regulating blood glucose control, leading to herbal treatment to manage diabetes from long time. Diabetes is proving to be a major problem throughout the world in the recent years. In spite of synthetic medications available in the market, to reduce the ill effects of diabetes and its secondary complications, herbal formulations are preferred due to less side effects and low cost. Objective: The present study attempts in studying antidiabetic property of an unexploited plant, Exacum pedunculatum, belonging to Gentianaceae family, from the Western Ghats of India. Methodology: The dried plant material was subjected to extraction for isolating compounds which was purified to obtain biguanide compound and screened in silico to study the antidiabetic nature of the compound. Result: Promising phytochemicals are present in the extract of the plant. Exacum pedunculatum which was further studied in silico for the drug activity. The experiment showed that the bioactive compound isolated from the selected plant showed higher activity than the drug molecule (Metformin) available in the market. Conclusion: As diabetes is a multifactorial disease leading to several complications, and demands a multiple therapeutic approach; medicinal plants are being looked up once again for the treatment of diabetes. There is a need for conducting clinical research in herbal drugs, developing simple bioassays for biological standardization, pharmacological and toxicological evaluation, and developing various animal models for toxicity and safety evaluation. It is also important to establish mechanism of action of the active components from these plant extracts.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Lakshmi Huttada, MB Hiremath and Niketan Laner D’Souza


Autodock, Diabetes, Exacum pedunculatum, Hexadecanoic acid, Metformin, Molecular docking, Traditional medicine, Glycosides Isoprenoids Natural Medicine

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version