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Research Article Open Access
Background: This study was to evaluate the effect of new spray-type oral moisturizer containing Poly-γ-glutamic acid (γ-PGA). γ- PGA can be classified as a pseudopolyamino acid, which contains only repeated glutamate units. Bacillus subtilis was isolated from natto, fermented soybean health food containing abundant γ-PGA. It reported that γ-PGA could absorb thousands of times more water than its own weight. Methods: 79 volunteers were randomly allocated to two groups. The experimental group used this new moisturizer, and the control group usednothing. The effect of moisturizer was investigated by measuring amylase activity by salivary amylase monitor, oral moisture by Mucus®, stimulated salivary flow rates at predetermine times. Results and Conclusion: In the amylase activity, there was not any significant difference in the control group. In the experimental group, a decline was admitted in baseline and after 30 minutes (p<0.01). In the oral moisture, there was not a significant difference in both groups. In the stimulated salivary flow rates, there was not a significant difference in the control group. In the experiment group, an increase was admitted at baseline and after 10, 20, and 30 minutes (p<0.01). These results suggest that new moisturizer was able to improve the environment in the mouth.
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Author(s): Shoichi Yamamoto, Hiroaki Yoshida, Tadashi Ohkubo, Hirohumi Sawai, Shosuke Morita
Xerostomia, Spray-type oral moisturizer, &gamma,-PGA, Oral health, Oral Moisturizer