alexa Abstract | Fishing for Precision in ALK-Rearranged Non-Small-Cell Lung Cancers
ISSN: 2471-8556

Oncology & Cancer Case Reports
Open Access

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Case Report Open Access

Abstract

Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) represent the current standard for identification of therapeutically relevant anaplastic lymphoma kinase (ALK) rearrangements in advanced non-small-cell lung cancers (NSCLCs). Use of tyrosine kinase inhibitors (TKIs) targeting the oncogenic ALK fusion protein is approved for use in advanced ALK-rearranged NSCLCs and with benefits both with regards to clinical outcomes and quality of life when compared with traditional palliative cytotoxic therapies. We report here 2 cases in which initial standard of care ALK testing by FISH yielded false positive results, leading to delays in determination of optimal systemic therapy.

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Author(s): Xiuning Le, Mary Linton Peters, Paul A VanderLaan, Daniel B Costa and Deepa Rangachari

Keywords

Fluorescence, anaplastic lymphoma, Liver Cancer Case Reports, Bone cancer, Skin Cancer

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