alexa Abstract | Formulation Development and Evaluation of Gastroretentive Bilayer Floating Tablets of Simvastatin and Telmisartan


Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

The objective of this present investigation is to design and evaluate the gastroretentive bilayer floating tablets of Simvastatin as controlled release and Telmisartan as immediate release. The combination therapy of Telmisartan and Simvastatin is useful in serious cardiovascular adverse effect such as hypertension, congestive heart failure and exacerbation of angina which may occur along with increasing cholesterol level in the blood, while the fixed dose combination remain the preferable choice to the patient as compared to the individual dosage form. Bi-layer tablet is suitable for sequential release of two drugs in combination, two incompatible substances and also for controlled release of drug. The bilayer tablets are prepared using different super disintegrants like Sodium Starch Glycolate, Cross Carmellose Sodium, Crospovidone for Telmisartan immediate release and xanthan gum, guar gum and HPMC K4M for Simvastatin controlled release. Sodium Bicarbonate is used as a gas generating agent. The precompression parameters like angle of repose, bulk density, tapped density; compressibility index and hausner’s ratio were studied. The tablets were characterized by physical and chemical parameters such as tablet Uniformity of weight, thickness, hardness, diameter, friability, drug content, swelling index and In vitro drug release. The optimized formulation based on all the parameter T-3(Crospovidone) was selected for immediate release layer, S-5(Xanthan gum and HPMC K4M) for controlled release layer and bilayer tablets were prepared. The dissolution data was subjected to various release kinetic models to understand the mechanism of drug release.

To read the full article Peer-reviewed Article PDF image

Author(s):  B. Prabakaran, K. Elango, K. Ramesh Kumar, D Jaison

Recommended Journals

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords