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Research Article Open Access
A number of Indian medicinal plants have been used for thousands of years in traditional system of medicine. Stephania wightii is an important member of Menispermaceae family. It is an endemic to the southern Western Ghats, India. The aim of this study was to investigate the free radical scavenging activity of S. wightii. The methanolic extract of aerial parts and tuber of S. wightii were used for this study. The extracts were assayed for radical scavenging activity, using the stable free radical diphenylpicrylhydrazyl, OH radical and nitric oxide radicals scavenging activity. The IC50 values of methanol extract of aerial parts and tuber on DPPH radical, hydroxyl radical and nitric oxide radicals scavenging were found to be 10-30μg/ml, respectively. The free radical scavenging activity of the plant extracts may be due to the presence of phytoconstituents. In all the methods, the methanolic tuber extract has exhibited the good scavenging activity compared to the aerial parts extract. It may have promising antioxidant agents and may also helpful in the treatment of the diseases caused by free radicals.
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Author(s): U. Danya, M.R. Udhayasankar, D. Punitha and K. Arumugasamy