alexa Abstract | Functional Analysis of 3-Mercaptopyruvate Sulfurtransferase Using Knockout Mice
ISSN: 2379-1764

Advanced Techniques in Biology & Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Mini Review Open Access


3-mercaptopyruvate sulfurtransferase (MST) transfers sulfur from 3-mercaptopyruvate (3MP) or thiosulfate to a sulfur acceptor. We developed MST-knockout (MST-KO) mice to clarify the physiological role of MST. They showed increased anxiety-like behaviors. In the prefrontal cortex and hippocampus, levels of serotonin (5-hydroxytryptamin, 5-HT) and/or serotonin metabolite, 5-hydroxyindoleacetic acid were higher in MST-KO mice than in wild-type mice and further 5-HT2A receptor mRNA was increased. Experiments using MST-KO mouse revealed that MST produces hydrogen polysulfides from 3MP and sodium sulfide and hydrogen trisulfide was also enzymatically produced.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Yusuke Suwanai, Noriyuki Nagahara, Zenya Naito and Hideo Orimo


3-Mercaptopyruvate sulfurtransferase, Knockout mice, Mercaptolactate-cysteine disulfiduria, Serotonin, 5-Hydroxyindoleacetic acid, Serotonin receptor, Anxiety-like behavior, Methods in Molecular Biology, Genetics Techniques, Sampling Techniques in Biology

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version