alexa Abstract | Genealogy of the Genome Components in the Highly Homogeneous Pandemic Vibrio parahaemolyticus Population
ISSN: 2329-9002

Journal of Phylogenetics & Evolutionary Biology
Open Access

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Research Article Open Access

Abstract

Bacterial genomes evolve through two different mechanisms: 1) changes in or occasional loss of ancestral genes, which preserve the founder clonal genealogy or frame, and 2) sporadic gains of new genes via horizontal gene transfer, which introduces DNA with a different genealogy or clonal frame. Evolution has led to the emergence of a pathogenic strain pandemic of Vibrio parahaemolyticus, which has propagated globally, causing large outbreaks of seafood-associated diarrhea. The low sequence diversity of the pathogenic strain of Vibrio parahaemolyticus genome provides a model that can reveal evolutionary mechanisms that are hidden in bacteria with a greater diversity. Here, we assess the clonal genealogy of the genome components of Vibrio parahaemolyticus and identify recombinant segments in 31 isolates obtained worldwide. By comparing whole genomes using a procedure that accounts for at least 98% of the reads obtained from any isolate after high throughput sequencing, we determined that the fraction of the whole genome retaining the founder clonal frame varied from 96.7%-100% of the accountable reads. The fraction in chromosomes with other genealogies varied from 0%-3.3% and in extra-chromosomal elements from 0%-4.2%, with the relative impact of mutation and recombination varying greatly between isolates. The likely causes for this variation are proposed.

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Author(s): David E Loyola, Cristian Yañez, Nicolas Plaza, Katherine García and Romilio T Espejo*

Keywords

Bacterial, Genome, Evolution, Phylogeny, Clones, Gene transfer, Phylogenetic Analysis, Evolutionary Systems Biology

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