alexa Abstract | Inhibition of Tumors in Mice Models by a Synthetic Ceramide-analog AD2725
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

A synthetic analog of ceramide (AD2725) elevated ceramide levels in MDA-MB-435 breast cancer cells inducing apoptosis and resulted in cell death. In animal studies, using a model of xenograft breast cancer cancer cells in nude mice, treatment with AD2725 resulted in a significant reduction of the tumor volume and weight, and a significantly prolonged survival of the treated mice. The analog also significantly elevated INF gamma and IL-12 cytokine levels and reduced the level of IL-10 in the plasma. These data indicate that use of suitable synthetic analogs that most probably elevate the ceramide levels may have beneficial anti-cancer therapeutic effects.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Qin JD, Weiss L, Zeira M, Yekhtin Z, Slavin S, Gatt S and Dagan A

Keywords

Ceramide, Sphingolipids, Apoptosis, Cytokine, Breast cancer, Biochemical pharmacology

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords