Journal of Obesity & Weight Loss Therapy
Open Access

Research Article

Irregular External Gastric Stimulation is Associated with Suppression of Serum Ghrelin Levels and Prolonged Decrease in Weight: A Novel Method for Sustaining Weight Loss

Gastroenterology and Liver Units, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

*Corresponding Author:

Yaron Ilan, MD
Gastroenterology and Liver Units
Department of Medicine
Hadassah-Hebrew University Medical Center
Jerusalem, POB 1200, IL-91120, Israel
Tel: 972-2-6778231
E-mail: ilan@hadassah.org.il

Received date: October 21, 2016; Accepted date: December 03, 2016;; Published date: December 06, 2016

Citation: Khoury T, Elbaz A, Rotnemer-Golinkin D, Shabat Y, Zolotarovya L, et al. (2016) Irregular External Gastric Stimulation is Associated with Suppression of Serum Ghrelin Levels and Prolonged Decrease in Weight: A Novel Method for Sustaining Weight Loss. J Obes Weight Loss Ther 6:327. doi:10.4172/2165-7904.1000327

Copyright: © 2016 Khoury T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Introduction: Weight regain is a major obstacle for most dietary procedures. Gastric stimulation has been shown to affect hormone levels.
Aim: The aim of the present study was to determine the effect of irregular external gastric stimulation on longterm weight reduction.
Methods: External gastric stimulation was performed by holding a rotator device on the abdomen of mice for 5 minutes in a regular or irregular manner. Mice were assessed for body weight and serum ghrelin levels. Results: External gastric stimulation was associated with a significant decrease in serum ghrelin levels. Irregular external gastric stimulation was associated with a prolonged effect on body weight reduction compared with regular stimulation. By the end of week 5, the body weight of untreated control mice had increased compared with a slight weight increase in mice treated with regular stimulation, while there was a significant continued decrease in the body weight of mice treated with irregular stimulation.
Conclusions: Irregular gastric stimulation is associated with a prolonged effect on weight loss and provides a method for overcoming the brain-gut axis accommodation of weight loss.

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