Journal of Infectious Diseases & Therapy
Open Access

Review Article

Isoniazid with Multiple Mode of Action on Various Mycobacterial Enzymes Resulting in Drug Resistance

Bioinformatics Centre, Biochemistry & JBTDRC, MGIMS, Sevagram, Maharashtra, India

*Corresponding Author:

Harinath BC
JB Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences
Sevagram, 442 102 (Wardha) Maharashtra, India
Tel: 91-7152–284341-284355
Fax: (07152)-284038
E-mail: bc_harinath@yahoo.com

Received date: September 11, 2016; Accepted date: October 17, 2016; Published date: October 20, 2016

Citation: Jena L, Nayak T, Deshmukh S, Wankhade G, Waghmare P, et al. (2016) Isoniazid with Multiple Mode of Action on Various Mycobacterial Enzymes Resulting in Drug Resistance. J Infect Dis Ther 4:297. doi:10.4172/2332-0877.1000297

Copyright: © 2016 Jena L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Isoniazid (INH), is one of the drugs shown to be effective and has been extensively used in TB control. Interestingly tuberculosis showed predominant drug resistance to isoniazid and thus lead to multi drug therapy in TB treatment. However, isoniazid is still advocated in latent TB and use as prophylactic in HIV infection and in children for prevention of TB. It is of interest that different studies revealing interaction of isoniazid with around 117 enzymes of mycobacteria influencing metabolic pathways by number of ways in addition to inhibiting mycolic acid synthesis and thus affecting growth of mycobacteria. The purpose of this review is to present the various mechanisms of action of isoniazid at different enzymes of MTB causing drug resistance.

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