Cardiovascular Pharmacology: Open Access

Abstract

Laparoscopic Sleeve Gasterectomy Reduces Inflammation and Cardiometabolic Risk in Obese Patients

FG Nazirov, ZR Khaybullina, SH KH Khashimov and UM Makhmudov

Obesity is associated with Metabolic Syndrome (MetS) and high cardiovascular risk as well as inflammation. Bariatric surgery is the most effective treatment of obesity and cardiovascular risk reduction. The aim of this research was to evaluate the Laparoscopic Sleeve Gasterectomy (LSG) effect on cardiometabolic risk factors, proinflammatory cytokines and oxidative stress markers in 25 women with morbid obesity (body mass index=45.4 ± 2.0 kg/m2). LSG is mini-invasive operation without radical reconstruction of gastrointestinal tract. It was established that after LSG there were no activation of inflammation, in contrast, there was reduction of proinflammatory cytokines (interleykin-6, tumor necrosis factor-alpha) and C-reactive protein in the blood at early (7th day) and late (3 month) period after operation. LSG led to a decrease in body weight and reduces cardiometabolic risk by normalizations of lipidomic profile (high-density lipoprotein cholesterol, triglyceride concentration in blood), optimizing the visceral fat tissue metabolism and reduction of inflammation and oxidative stress.