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Research Article Open Access
Abstract Objective: The feasibility of intra-arterial chemotherapy for local recurrent extremity osteosarcoma with prosthesis replacement. Methods: 9 local recurrent limb osteosarcoma patients with prosthesis replacement who received treatment during the period from April 2010 to June 2013 at our hospital were recruited, including 3 patients with lung metastasis. All patients were treated with intra-arterial chemotherapy via implanted pump at affected limb. Results: The local recurrent neoplasms calcified and formed clear boundary with normal tissues after 3 to 5 cycles intra-arterial intervention chemotherapy, which indicates the osteosarcoma was controlled effectively to facilitate the osteosarcoma excision. No local recurrence happened during the follow-up visit varied from 12 to 38 months. The late result was better in 6 patients without lung metastasis than 3 patients with lung metastasis, 2 of who died and 1 currently survive without tumor. Conclusion: Intra-arterial intervention chemotherapy could effectively curb the progress of local recurrent osteosarcoma to facilitate the subsequent limb salvage treatment, and prolong the lifetime of patients with lung metastasis.
Osteosarcoma, Local recurrence, Intra-arterial chemotherapy, Limb salvage, Osteosarcoma, Local recurrence, Intra-arterial chemotherapy, Limb salvage