alexa Abstract | α-Lipoic Acid Exerts a Primary Prevention for the Neointimal Hyperplasia in Balloon-Injured Rat Carotid Arteries

Journal of Pharmacological Reports
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Background: It has been reported that α-lipoic acid is an anti-oxidative and anti-inflammatory agent, and exhibits beneficial effects in experimental disease models such as hypertension and acute kidney injury. In the present study, we examined effects of α-lipoic acid on neointimal hyperplasia in balloon-injured carotid arteries. Methods: Male rats underwent balloon injury of the right carotid artery with a 2F Fogarty balloon catheter. α- Lipoic acid was administrated to balloon-injured rats in the following treatment schedules; (1) days -3 to 14, (2) days -3 to 3, (3) days 7 to 14 and (4) vehicle. We evaluated the neointimal formation, NADPH oxidase-dependent superoxide production, nitrotyrosine expression and p50 subunit of nuclear factor kappa B (NF-κB p50) expression in balloon-injured and uninjured carotid arteries. Results: In vehicle-treated rats, a significant neointimal formation was observed at 14 days after balloon injury in the carotid artery, and NADPH oxidase-dependent superoxide production, nitrotyrosine expression and NF-κB p50 expression in injured right carotid arteries significantly increased at 2 days after balloon injury as compared with uninjured left carotid arteries. The long-term treatment (initiated 3 days before surgery and continued for 14 days after balloon injury; days -3 to 14) with α-lipoic acid (100 mg/kg/day) markedly reduced the neointimal formation, NADPH oxidase-mediated superoxide production, nitrotyrosine and NF-κB p50 expression. The superoxide production, nitrotyroeine and NF-κB p50 expression at 2 days after balloon injury were significantly inhibited by the short-term treatment with α-lipoic acid (days -3 to 2). The short-term treatment (days -3 to 3) also could suppress the neointimal formation at 14 days after balloon injury. Conclusion: The present study suggests that the treatment with α-lipoic acid leads to a reduction of neointimal formation, probably by inhibiting enhanced superoxide production, nitrotyrosine and NF-κB p50 activation in an early phase after balloon injury.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Daisuke Kurumazuka, Hisashi Shirakawa, Sayaka Kimura, Tatsuhiko Mori, Yasuo Matsumura and Masanori Takaoka


-, -

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version