Chemotherapy: Open Access
Open Access

Abstract

Lmdd-MPFG Prevents HCC Occurrence through Dendritic Cells Related Signaling Pathways

Yun Chen and Xin Wan

Hepatocellular carcinoma is the most common and deadliest form of primary liver tumors with limited treatment options. Immunotherapy is a rising promising treatment in recent years. An attenuated hepatocellular carcinoma-specific Listeria vaccine (Lmdd- MPFG, LM), constructed by is proven to have potency to induce a strong and specific anti-tumor cellular immunity to HCC [1]. It has been proven that dendritic cells (DCs) play an essential role in Lm infection. In this paper, the researchers elucidated the valuable mechanism how DC initiates and induces anti-HCC immunity by Lmdd-MPFG vaccine