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Mini Review Open Access
Wound healing and repair is a physiologic process that occurs following tissue injury often resulting in a controlled scar formation. However, in certain disease states, the intrinsic mechanisms that signal the completion of repair are defunct leading to continued repair, resulting in excessive fibrosis. Numerous segments of the wound healing process are known to be deregulated in idiopathic pulmonary fibrosis (IPF) including increased myofibroblast activation, excessive extracellular matrix (ECM) deposition, and decreased injury resolution. In this review we will focus on one part of the wound healing process, lymphangiogenesis and lymphatic remodeling, and its potential role in the pathogenesis of pulmonary fibrosis.
Lymphangiogenesis, Lymphatic vessels, Idiopathic pulmonary fibrosis, Abdominal Aortic Aneurysm, Arteries, Arteriosclerosis, Blood Clot Symptoms, Brain Aneurysm Symptoms, Carotid Artery, Femoral Artery, Heart Disease, Hypotension, Ischemic Heart Disease, Peripheral Vascular Disease, Stent, Vascular, Vascular Dementia, Aortic aneurysm, Endovascular repair, Occluded mesenteric arteries