Tounsia Abbas-Aksil, Moussa Abbas, Mohamed Trari and Salem Benamara
The present study aimed to elaborate matrix tablets from powder mixture (2:1 ratio) of Algerian date (Phoenix dactylifera L.) fruit and lyophilized berries (Arbutus unedo L.) (LB), using the direct compression technique. In a first part, the physicochemical properties, including the X-ray diffraction, of individual powders and their mixture were determined. In the second step, the swelling, erosion and in vitro release rate characteristics of tablets were studied. The dissolution study of tablets is evaluated throughout the electric conductivity (EC) of surrounding medium (distilled water). Among the four tested models, namely zero-order, first-order, Higuchi and Korsmeyer-Peppas, the latter seems to be the most appropriate (R2=0.972-0.989) to describe kinetics of the ionic transfer whatever the applied temperature. Further, the activation energy (17.272 kJ/mol) related to the transfer mechanism is obtained from the Arrhenius plot with a correlation coefficient greater than 0.899. Globally, the physicochemical parameters of obtained tablets were found to be in compliance with the pharmacopoeial standards.
