alexa Abstract | MHC Class 1-Related Chain A and B Ligands are Differently Expressed in Cancer Cell Lines

Immunological Disorders & Immunotherapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article Open Access


The MHC class I related chain A and B have been of much interest in the recent past MHC class 1 related gene A/B (MICA/B) are ligands of the NKG2D, which is an activating receptor expressed on T and NK cells (NK cells are effector cells of the innate immune system and their functions are regulated by a number of killer cell-inhibitory and -activating receptors.).Their expression on normal tissues is highly restricted but in the event of tissue transformation and infected cells, MICA/B expression is up-regulated leading to NK killing activity. MICA/B are shedded in the serum of cancer patients (sMICA/B) whereby sustained expression of this MIC affects the killing activity of NK cells and T cells. In this summary review we look at how differently MIC A/B is expressed in Cancer cell.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Oremo JAA, Zhang Xiao and Zhu Sha


MHC class 1 related chain A and B, Natural killer, NKG2D, Soluble MIC A/B, Perth beta block transcript, Adjuvant Immunotherapies, Immune Specific, Autoimmune Lupus

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version