alexa Abstract | MicroRNAs as Biomarkers of the Response to Treatment with ABVD Scheme in Hodgkin Lymphoma
ISSN: 2329-6917

Journal of Leukemia
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Hodgkin Lymphoma (HL) is a neoplasia characterized by the restrict number of malignant cells present in the lymph node. Actual criteria in diagnostic standards don’t consider genetic and epigenetic alterations as risk factors in the development of this disease or in the response of the treatment. MicroRNAs (miRNAs) are important regulatory elements of genic expression that can be altered in the presence of cancer. New advances in the field suggest miRNAs as HL biomarkers. We evaluated the expression profiles of five miRNAs (hsa-miR-9, hsa-miR-20a, hsamiR- 21, hsa-miR-26a and hsa-miR-155) in the peripheral blood of three groups of patients: patients diagnosed with HL who had not received any radiologic or chemotherapeutic treatment; patients diagnosed with HL who had been treated with the Adriblastin, Bleomycin, Vinblastine and Dacarbazine (ABVD) chemotherapeutic scheme; and a control group consisting of healthy volunteers without HL. Our results showed that the expression profiles of hsamiR- 9, hsa-miR-21, hsa-miR-26a and hsa-miR-155 were able to significantly distinguish untreated HL patients from patients without the disease and that the hsa-miR-9, hsa-miR-21 and hsa-miR-155 expression profiles were altered by treatment with ABVD. These results suggest that miRNAs are promising blood biomarkers of HL and also a possible biomarkers of the response to ABVD treatment.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Ana Virgínia Van Den Berg, Leandro Magalhães, Amanda Ferreira Vidal, Aline Maria Pereira Cruz and Ândrea Ribeiro-dos-Santos


MicroRNAs, Biomarkers, Response to treatment, ABVD scheme, Hodgkin lymphoma, Biomarkers, Hodgkin Lymphoma

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version