alexa Abstract | Molecular Behavior of CENP-A and PCNA throughout the Cell Cycle in Living Human HT-1080 Cells
ISSN: 2168-9547

Molecular Biology: Open Access
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Research Article Open Access

Abstract

Centromere is the chromosomal region to which spindle microtubules attach in mitosis. Centromere protein A (CENP-A), a centromere-specific histone H3 variant [1], was originally identified by anti-centromere autoantibodies [2]. Human CENP-A is assembled into prekinetochores in G1 phase, and is stably maintained through multiple cell divisions [3]. We previously reported the relative position of three centromere auto antigens, CENP-A, CENP-B, and CENP-C, in human MDA435 cells in interphase nuclei and metaphase chromosomes [4]. We then characterized the molecular behavior of CENP-A and heterochromatin protein 1α (HP1α) during mitosis in living MDA435 cells [5]. Recently, Lidsky et al. reported the dynamics of Cid/CENP-A, CENP-C, and Cal 1 in Drosophila S2R+ cells, and presented the live-cell images stably expressing the Cid-EGFP and mCherry-PCNA through the cell cycle [6]. However, the localization of mammalian CENP-A throughout the cell cycle in living cells is unclear.

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Author(s): Kenji Sugimoto

Keywords

Centromere protein A (CENP-A), Proliferating cell nuclear antigen (PCNA), Replication focus, Cell cycle, Live-cell imaging, Centromere protein A (CENP-A), Proliferating cell nuclear antigen (PCNA), Replication focus, Cell cycle, Live-cell imaging

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