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Case Report Open Access
We report the rare occurrence of multiple metachronous malignancies in three patients within different time frames from 18 months, 7 years and up to 25 years, respectively. Multiple primary malignant neoplasias (MPMN) are extremely rare. The key risk factors may be smoking and family history. While numerous studies have been published on the development of secondary malignancies following a first primary, the literature contains only few reports of patients with multiple metachrounous malignancies.
Multiple primary malignant neoplasms (MPMN), Small cell lung cancer (SCLC), Non-small cell lung cancer (NSCLC), Eastern cooperative oncology group (ECOG), C-reactive protein (CRP), Epidermal growth factor receptor (EGFR) , Liver Cancer Case Reports, Bone cancer, Skin Cancer