alexa Abstract | Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan
ISSN: 2167-7182

Journal of Gerontology & Geriatric Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

We investigated the role of metabolic memory in a choice of strategies for adaptation to stress influences. We used a model of rat overeating in early ontogenesis from birth to 21 days of life and investigated the maintenance of formed metabolic pattern in later ontogenesis. The following characteristics were measured: somatometric indicators, resistance of animals to a temperature stress of 32ᵒC, thyroxin and triiodothyronine content in blood serum, NO-synthase activity, the content of lipid hydroperoxides and antioxidant enzymes in different organs in animals of 3, 20 and 31 months of age under standard conditions of maintenance in control animals and after overeating in the early ontogenesis. It is shown that the metabolic pattern formed on the background of overeating from birth to 21 days remains until the later stages of ontogeny. The forming metabolic pattern is characterized by elevated content of thyroxin, increase of NO-synthase activity in various tissues and particularly in the brain, a small increase of lipid hydroperoxides and reduced antioxidant activity of some enzymes. Animals that overeated in the early ontogenesis, are characterized by lower resistance to high temperatures and shorter life expectancy compared to the animals contained in the standard terms.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Bozhkov AI*, Nikitchenko Yu V and Al-Bahadly Ali MM

Keywords

Clinical Geriatrics,Critical Gerontology,Geriatric

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords