alexa Abstract | PBK/TOPK as a Potential Therapeutic Target in Glioblastoma and Other Malignancies
ISSN: 2168-9547

Molecular Biology: Open Access
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Abstract

A serine/threonine kinase PDZ binding-kinase (PBK) is a member of the mitogen-activated protein kinase (MAPK) kinase (MAPKK) family. This enzyme is also known under the name T-lymphokine-activated killer cell-originated protein kinase (TOPK). PBK was discovered as a factor that binds PDZ2 domain of hDLg (human homologue of the Drosophila Discs-large (Dlg) tumor suppressor protein).This study also demonstrated that the mitotic phosphorylation of PBK is required for its kinase activity.

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Author(s): Biljana Stangeland

Keywords

PBK/TOPK, Tumor, Cell cycle, Glioblastoma, Glioblastoma initiating cells, shRNA, PBK/TOPK, Tumor, Cell cycle, Glioblastoma, Glioblastoma initiating cells, shRNA

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