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Research Article Open Access
Three pentacyclic triterpenes, named betulinic acid (1), 11α-hydroxy-β-amyrin (2) 3β-acetoxy-20 (29)-lupen- 28-aldehyde (3) were isolated from the ethyl acetate fraction of the bark of Platanus acerifolia Willd. The molecular structure of 1 and were established on the basis of various spectroscopic analyses. The molecular structure of (3) was determined by single-crystal X-ray diffraction. Compound (2) and (3) were obtained from the title plant for the first time. Cytotoxicity of the isolated compounds against three human cancer cell lines, HepG-2, MCF-7 and HL-60 were also determined with the cell counting kit-8 (CCK-8) assay. The target compounds showed the high cytotoxicity, with IC50 values in the range 2.2-9.1 μM. These results indicated that pentacyclic triterpenes from the bark of Platanus acerifolia Willd could be explored as potential cancer prevention agents.
Pentacyclic triterpenes, Platanus acerifolia Willd bark, Antitumor activity in vitro, Modern Physical Organic Chemistry, Modern Experimental Chemistry