alexa Abstract | Preparation of Polymeric Micelles of Curcumin with Pluronic P123 and Assessment of Efficacy against B16 Cells In Vitro
ISSN: 2167-1052

Advances in Pharmacoepidemiology and Drug Safety
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Polymeric micelles of curcumin were obtained using Pluronic P123 to increase the solubility and bioavailability of curcumin. The curcumin-P123 micelles were prepared by a thin-film dispersion method and the content of curcumin was determined by high-performance liquid chromatography. The entrapment efficiency was optimized by an orthogonal design to determine the best preparation method. The microscopic morphology, diameter, and drugloaded amount of the micelles were determined by transmission electron microscopy, particle size distribution, Fourier transform, and X-ray diffraction. The in vitro drug release rates were measured by a dialysis method. The entrapment efficiency of curcumin was 94.7% and the loading capacity was 3.06% under optimized conditions (curcumin 5 mg, Pluronic P123 150 mg, water 10 mL, and methanol 10 mL). The average size and zeta potential of the round or ellipse polymeric micelles were 117.23 ± 2.57 nm and 7.87 ± 2.50 mV, respectively, with uniform particle size distribution. The polymeric micelles were dispersed into block copolymers in molecular and amorphous forms based on X-ray diffraction and FTIR analysis. The polymeric micelles of curcumin showed significant sustained drug release in vitro compared with a pharmaceutical solution. The anti-tumor efficacy of curcumin-P123 on B16 cells was assessed in vitro by a (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The antitumor effects of the polymeric micelles was higher than that of curcumin. The prepared curcumin-P123 micelles increased the drug solubility in the aqueous phase. The polymeric micelles of curcumin have an important effect and excellent research value because of their sustained drug release and excellent inhibitory effect on tumor cells.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Kunquan Su, Yunxu Yang, Qiuping Wu, Yingying Mao and Ying Hu


Curcumin, Pluronic P123, Polymeric micelles,Orthogonal design, X-ray diffraction, (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), Adverse Drug Reactions, Drug Delivery

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version