alexa Abstract | Prospects of Differentiation Therapy for Cancer Stem Cells
ISSN: 2379-1764

Advanced Techniques in Biology & Medicine
Open Access

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Abstract

The subpopulation of cancer stem cells (CSCs) in tumor tissues drives tumorigenesis and causes the infiltration of cancer cells to surrounding tissues. CSCs are considered to induce tumor initiation, progression, and relapse. Conventional chemotherapies eliminate bulk tumors; however, CSCs evade most therapies. We recently showed that differentiation of CSCs in hepatocellular carcinoma diminished malignant phenotypes. The best strategy for CSC-targeting therapy is yet unknown, however, it appears that differentiation therapy would be effective for certain types of tumors. In this review, we discuss the characteristics of CSCs and prospective use of differentiation therapy for cancer stem cells.

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Author(s): Shigekazu Murakami and Fumio Tashiro

Keywords

Cancer stem cells, Differentiation therapy, Chemoresistance, Hepatocellular carcinoma, SRY, OCT4, ABC transporter, Methods in Molecular Biology, Cancer stem cells, Differentiation therapy

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