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Research Article Open Access
The study was intended to appraise the shielding effect of earthworm powder (EWP) against isoproterenol induced myocardial infarction in wistar male rats. The animals were orally pretreated with EWP (200mg/kg b.wt.) (group III) for 30 days and then intoxicated with isoproterenol (85 mg/kg b.wt. administered subcutaneously twice at an interval of 24 hrs) (group II). Group IV animals were pre-treated with atrovastatin (40mg/kg b.wt. administered subcutaneously twice at an interval of 24h) for 30 days, 85 mg/kg b.wt. of isoproterenol was given by subcutaneously injection twice at an interval of 24h. Animals were orally pretreated with 200mg/kg b.wt EWP for 30 days (group V). Isoproterenol intoxicated myocardial infarction was confirmed by disturbances in serum and cardiac markers namely creatinine kinase (CK), creatinine kinase – muscle brain (CK-MB), and troponin T (CnTn), aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). ISO induced rats showed specific amelioration in the levels of these enzymes in serum and heart which tends them to get elevated in myocardium. The levels of these enzymes accomplish normalcy as observed in EWP pretreated rats. Histopathological evidence also supports the curing effect of EWP against isoproterenol. Pretreatment with EWP ameliorate the elevation of ISO induced pathological changes, reduced the lipid peroxide formation and retained the myocardial maker enzyme activities at near normal. Thus the result at hand is in concordance with the view that EWP is proficient in combating myocardial free radical damage aggravated by ISO thus proving its protective role.
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Author(s): J. Anitha,Indira A. Jayraaj
Cardiac markers, earthworm powder, Eudrilus eugeniae, myocardial infarction, isoproterenol, Cardiac Toxicity