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Research Article Open Access
Two simple, specific, accurate and economical UV-Spectrophotometric methods were developed and validated for quantitative determination of Rosuvastatin and niacin in combined tablet dosage form. Method I is based on the simultaneous equation and method II is based on the absorbance ratio method. The solvent used to develop the method was Double distilled water. The absorbance maxima were found to be at 241and 262nm in water for the Rosuvastatin and niacin respectively. Beer’s law is obeyed in the concentration range 5-40μg/ml with correlation coefficient within range of 0.998 for both the drugs. The accuracy of the method was checked by recovery experiment performed at three different levels i.e., 50%, 100% and 150%.The % recovery was found to be 98-105% for Rosuvastatin and niacin respectively. The low values of % R.S.D are indicative of the accuracy and reproducibility of the method. The % R.S.D value less than 2 indicate that the method is precise. The above method was a rapid and cost-effective quality-control tool for routine analysis of pharmaceutical dosage form.
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Author(s): Narayankar Savita M, Sakpal Promod H, Bhingare Chandrashekhar L